Week 7: Pushing CRISPR One Step Further

This week we heard each other’s presentations for the various CRISPR applications and I was most interested in the one presented by Sophia, whereby the paper investigated the use of hairpin secondary structures to improve accuracy. I feel like there would be a lot of potential if they are able to show more accurate evidence of its effectiveness because forming the hairpin structure itself appears quite simple and straightforward. However, being based on mathematical modelling, I had a tinge of doubt towards the accuracy of the results, more so when there were no previous studies or reasons sited for choosing their modelling software used. From this it made me question how easy it is for us to take for granted certain methodology, especially when it is either well-established or commonly used.

Personally, I thought it would be easier to analyse a short paper, but I was proven wrong. My own paper was theoretical in nature so, in terms of methodology and materials, I really struggled to find points to critique. But at the same time, the short article made me appreciate every line that was written, after having combed through each line over and over again. While critiquing the paper, I kept wondering, “Why didn’t they include this (or that)?”, and that is when I realised how important it is to accurately communicate information in a succinct manner. There are certain things that seem important but may not be relevant to the current proposition. The author has to re-evaluate the direction and focus of the paper and ascertain if the content is in line with the message to be conveyed.

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