Week 3: SCIEX and CRISPR/Cas

I really enjoyed the field trip to SCIEX this week. I think that it is interesting to see how companies optimise their operations and also as a biotech company, how they continue to innovate and improve in an iterative fashion. They take into account not only customer feedback but even things like walking distance to optimise associate work efficiency.

As for the science technology, I think that its great that they are looking at forecasting the trends for mass spec analysis instead of just waiting on their customer demands. Having the best of both worlds in the QTRAP system is great for the future when we might be looking to analysing greater amounts in a shorter period of time, we will need to rely more on qualitative screening.

For lecture and reading, I enjoyed the review papers assigned to us. Gave me a comprehensive understanding of the mechanics of CRISPR/Cas9 system as well as the future modifications that can be done to it. Prof Liou did a good job in reiterating the reading material again, as well as the difference and advantages between RNAi and CRISPR. I think that RNAi has a lot of potential but it’s right to say that there is a lot of difficulty in getting it approved due to the off-target effects. Patisiran is the first RNAi approved as a therapeutic, so I think that there is way more that can be worked on this area.


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